HepG2 cells were subjected to SDS PAGE followed by western blot with FNab04939(MAGEA6 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human lung cancer using FNab04939(MAGEA6 antibody) at dilution of 1:50
Background
Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme(E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines.