Products
CHTF18 antibody
- Product Name
- CHTF18 antibody
- Catalogue No.
- FNab01701
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- CTF18, chromosome transmission fidelity factor 18 homolog
- Alternative Names
- Chromosome transmission fidelity protein 18 homolog (hCTF18)|CHL12|CHTF18|C16orf41|CTF18 antibody
- UniProt ID
- Q8WVB6
- Observed MW
- 120 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500-1:1000; IHC: 1:20-1:200
Validated Images
Y79 cells were subjected to SDS PAGE followed by western blot with FNab01701(CHTF18 antibody) at dilution of 1:300
Immunohistochemistry of paraffin-embedded human cerebellum using FNab01701(CHTF18 antibody) at dilution of 1:100
- Background
- Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C(CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A(RPA) and by proliferating cell nuclear antigen(PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase POLH.
