Products
CD22 antibody
Category:
Research Area:
- SPECIFICATIONS
- Product Name
- CD22 antibody
- Catalogue No.
- FNab01444
- Size
- 100μg
- Form
- liquid
- Purification
- Protein A+G purification
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- monoclonal
- Isotype
- IgG1
- Clone ID
- 7D10
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- CD22 molecule
- Alternative Names
- B cell receptor CD22 antibody, BL CAM antibody, CD22 antibody, CD22 molecule antibody, SIGLEC 2 antibody, SIGLEC2 antibody, T cell surface antigen Leu 14 antibody
- UniProt ID
- P20273
- Observed MW
- 135 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB : 1:1000-1:10000; IHC : 1:500-1:2000
Validated Images
Raji cells were subjected to SDS PAGE followed by western blot with FNab01444(CD22 antibody) at dilution of 1:5000
Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using FNab01444(CD22 Antibody) at dilution of 1:400
- Background
- Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.