K-562 cells were subjected to SDS PAGE followed by western blot with FNab00238(AIM2 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human testis using FNab00238(AIM2 antibody) at dilution of 1:100
Background
Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8(By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.