HeLa cells were subjected to SDS PAGE followed by western blot with FNab06645(POT1 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded mouse lung using FNab06645(POT1 antibody) at dilution of 1:100
Background
This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described.