mouse lung tissue were subjected to SDS PAGE followed by western blot with FNab05976( OGDH Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded mouse brain using FNab05976(OGDH antibody) at dilution of 1:100
Background
This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.