HepG2 cells were subjected to SDS PAGE followed by western blot with FNab03993(HPD antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded rat kidney using FNab03993(HPD antibody) at dilution of 1:100
Background
The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene.