mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab03442(GGA2 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human stomach using FNab03442(GGA2 antibody) at dilution of 1:100
Background
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly.