HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab01615(CES1 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human liver cancer using FNab01615(CES1 antibody) at dilution of 1:100
Background
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene.