Products

anti- AGER antibody

FNab09951 Catalogue No.
Synonyms
AGER, RAGE
Host
Mouse
Reactivity
Human, Rat
Isotype
IgG1
Tested Application
ELISA, WB
Product Information
Product Name
anti- AGER antibody
Catalogue No.
FNab09951
Size
100µg
Form
liquid
Purification
protein A+G purified
Purity
≥95% as determined by SDS-PAGE
Host
Mouse
Clonality
monoclonal
Isotype
IgG1
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background
Mediates interactions of advanced glycosylation end products(AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling(By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide(ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase(MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.
Immunogen Information
Immunogen
advanced glycosylation end product-specific receptor
Synonyms
AGER, RAGE
Observed MW
43 kDa
Application
Tested Application
ELISA, WB
Recommended dilution
WB: 1:1000-1:5000
Uniprot information
UniProt ID
Q15109
Images
Rar lung tissue were subjected to SDS PAGE followed by western blot with FNab09951(AGER Antibody) at dilution of 1:2000