Products

ZAP70 antibody

Synonyms:70 kDa zeta associated protein antibody, FLJ17670 antibody, FLJ17679 antibody, SRK antibody, STD antibody, Syk related tyrosine kinase antibody, Tyrosine protein kinase ZAP 70 antibody, TZK antibody, ZAP 70 antibody, ZAP70 antibody
Catalogue No.:FNab09582Reativity:Human, Mouse
Host:RabbitTested Application:ELISA, WB, IHC
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
ZAP70 antibody
Catalogue No.
FNab09582
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
zeta-chain (TCR) associated protein kinase 70kDa
Alternative Names
70 kDa zeta associated protein antibody, FLJ17670 antibody, FLJ17679 antibody, SRK antibody, STD antibody, Syk related tyrosine kinase antibody, Tyrosine protein kinase ZAP 70 antibody, TZK antibody, ZAP 70 antibody, ZAP70 antibody
UniProt ID
P43403
Observed MW
69 kDa
Application
Tested Applications
ELISA, WB, IHC
Recommended dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Validated Images
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab09582(ZAP70 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human amygdalitis using FNab09582(ZAP70 antibody) at dilution of 1:50
Background
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.