Products
PTPN11 antibody
- Product Name
- PTPN11 antibody
- Catalogue No.
- FNab06932
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- protein tyrosine phosphatase, non-receptor type 11
- Alternative Names
- Tyrosine-protein phosphatase non-receptor type 11|Protein-tyrosine phosphatase 1D (PTP-1D)|Protein-tyrosine phosphatase 2C (PTP-2C)|SH-PTP2 (SHP-2 antibody, Shp2)|SH-PTP3|PTPN11|PTP2C|SHPTP2 antibody
- UniProt ID
- Q06124
- Observed MW
- 71 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500 - 1:1000; IHC: 1:50 - 1:100
Validated Images
HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab06932( PTPN11 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded rat heart using FNab06932( PTPN11 Antibody) at dilution of 1:100
- Background
- The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
