HepG2 cells were subjected to SDS PAGE followed by western blot with FNab04636(KPNA4 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human stomach using FNab04636(KPNA4 antibody) at dilution of 1:100
Background
The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen.