mouse kidney tissue were subjected to SDS PAGE followed by western blot with FNab02235(DAO antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human colon tissue FNab02235(DAO antibody) at dilution of 1:100
Immunofluorescence analysis of MCF-7 cells using FNab02235( DAO Antibody). Blue: DAPI for nuclear staining.
Background
This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia.