Products
AMBRA1 antibody
- Product Name
- AMBRA1 antibody
- Catalogue No.
- FNab00356
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- autophagy/beclin-1 regulator 1
- Alternative Names
- AMBRA1 antibody, autophagy/beclin 1 regulator 1 antibody, FLJ20294 antibody, KIAA1736 antibody, WDR94 antibody
- UniProt ID
- Q9C0C7
- Observed MW
- 140 kDa
Application
- Tested Applications
- ELISA, IHC, WB
- Recommended dilution
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Validated Images
mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab00356(AMBRA1 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded rat kidney using FNab00356(AMBRA1 antibody) at dilution of 1:50
- Background
- WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. AMBRA1 (Activating molecule in BECN1-regulated autophagy protein 1), also known as WDR94 or KIAA1736, is a 1, 298 amino acid protein that contains three WD repeats. Localized to cytoplasmic vesicles, AMBRA1 functions to control protein turnover, cell proliferation and cell survival during neuronal development, thereby playing an important role in autophagy and the development of the nervous system. Multiple isoforms of AMBRA1 exist due to alternative spicing events.
