A431 cells were subjected to SDS PAGE followed by western blot with FNab10472( NCR1 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human skin cancer slide using FNab10472( NCR1 Antibody) at dilution of 1:200
Background
The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. NCR1 is a glycoprotein that has two extracellular Ig-like domains followed by a ~40 amino acid residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. NCR1 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. NCR1 has been implicated in NK cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines.