Products
APTX antibody
- Product Name
- APTX antibody
- Catalogue No.
- FNab10359
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- aprataxin
- Alternative Names
- AOA antibody, AOA1 antibody, aprataxin antibody, APTX antibody, AXA1 antibody, EAOH antibody, EOAHA antibody, FHA HIT antibody
- UniProt ID
- Q7Z2E3
- Observed MW
- 40 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500 - 1:2000; IHC: 1:20 - 1:200
Validated Images
Various lysates were subjected to SDS PAGE followed by western blot with FNab10359(APTX antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded rat brain using FNab10359(APTX antibody) at dilution of 1:100
- Background
- APTX, also named as Aprataxin, is a nuclear protein, present in both the nucleoplasm and the nucleolus, which is a member of the histidine triad (HIT) superfamily. APTX is involved in DNA single-strand break repair, mediating protein-protein interactions with molecules responding to DNA damage. APTX contains three conserved domains: an N-terminal forkhead-associated (FHA) domain which mediates protein-protein interactions, a HIT domain that is similar to Hint, and a C-terminal zinc finger domain. Loss of function mutations in APTX, the gene encoding for Aprataxin, destabilize the Aprataxin protein and result in a rare neurological disorder known as ataxia-oculomotor apraxia, characterized by abnormal movements of the head and eyes.
