Products
UXT antibody
- Product Name
- UXT antibody
- Catalogue No.
- FNab09353
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- ubiquitously-expressed transcript
- Alternative Names
- ART 27 antibody, Protein UXT antibody, UXT antibody
- UniProt ID
- Q9UBK9
- Observed MW
- 18 kDa
Application
- Tested Applications
- ELISA, WB, IP
- Recommended dilution
- WB: 1:200-1:1000; IP: 1:200-1:1000
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab09353(UXT antibody) at dilution of 1:400
IP Result of anti-UXT (IP:FNab09353, 3ug; Detection:FNab09353 1:300) with mouse brain tissue lysate 4000ug.
- Background
- Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor transcription(AR). AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation(PubMed:11854421). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling(PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC(PubMed:17554592). May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function(PubMed:17620405). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM(PubMed:17635584). Together with URI1, associates with chromatin to the NKX3-1 promoter region.
