Products
TXNIP antibody
- Product Name
- TXNIP antibody
- Catalogue No.
- FNab09129
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- thioredoxin interacting protein
- Alternative Names
- EST01027 antibody, HHCPA78 antibody, THIF antibody, Thioredoxin binding protein 2 antibody, TXNIP antibody, VDUP1 antibody
- UniProt ID
- Q9H3M7
- Observed MW
- 50 kDa
Application
- Tested Applications
- ELISA, IHC, WB, IF
- Recommended dilution
- WB: 1:200-1:2000; IP: 1:200-1:2000; IHC: 1:50-1:500; IF: 1:10-1:100
Validated Images
K-562 cells were subjected to SDS PAGE followed by western blot with FNab09129(TXNIP Antibody) at dilution of 1:600
IP Result of anti-TXNIP (IP: FNab09129, 4ug; Detection: FNab09129 1:500) with K-562 cells lysate 4000ug.
Immunohistochemistry of paraffin-embedded human kidney tissue slide using FNab09129(TXNIP Antibody) at dilution of 1:200
Immunofluorescent analysis of HeLa cells using FNab09129 (TXNIP antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG(H+L)
- Background
- May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1(mTORC1).
