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TRPV6 antibody
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Synonyms: | ABP/ZF antibody, Calcium transport protein 1 antibody, CaT L antibody, CaT like antibody, CAT1 antibody, CATL antibody, ECAC2 antibody, Epithelial calcium channel 2 antibody, HSA277909 antibody, LP6728 antibody, TRPV6 antibody, ZFAB antibody | ||
Catalogue No.: | FNab09030 | Reativity: | Human, Mouse, Rat |
Host: | Rabbit | Tested Application: | ELISA, IF, WB, IP |
Clonality: | polyclonal | Isotype: | IgG |
- SPECIFICATIONS
- Product Name
- TRPV6 antibody
- Catalogue No.
- FNab09030
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- transient receptor potential cation channel, subfamily V, member 6
- Alternative Names
- ABP/ZF antibody, Calcium transport protein 1 antibody, CaT L antibody, CaT like antibody, CAT1 antibody, CATL antibody, ECAC2 antibody, Epithelial calcium channel 2 antibody, HSA277909 antibody, LP6728 antibody, TRPV6 antibody, ZFAB antibody
- UniProt ID
- Q9H1D0
- Observed MW
- 82 kDa,70 kDa
Application
- Tested Applications
- ELISA, IF, WB, IP
- Recommended dilution
- WB: 1:500-1:5000; IP: 1:200-1:1000; IF: 1:10-1:100
Validated Images
human placenta tissue were subjected to SDS PAGE followed by western blot with FNab09030(TRPV6 Antibody) at dilution of 1:1000
IP Result of anti-TRPV6 (IP:FNab09030, 4ug; Detection:FNab09030 1:300) with mouse kidney tissue lysate 4000ug.
- Background
- Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine(PubMed:11097838, PubMed:11278579, PubMed:11248124 PubMed:15184369, PubMed:23612980). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin(By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification(PubMed:15184369). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.