human heart tissue were subjected to SDS PAGE followed by western blot with FNab09016(TRPC4AP Antibody) at dilution of 1:300
IP Result of anti-TRPC4AP (IP:FNab09016, 5ug; Detection:FNab09016 1:200) with mouse heart tissue lysate 6000ug.
Immunohistochemistry of paraffin-embedded human breast cancer slide using FNab09016(TRPC4AP Antibody) at dilution of 1:50
Background
Substrate-specific adapter of a DCX(DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.