Products
TRK fused gene antibody
- Product Name
- TRK fused gene antibody
- Catalogue No.
- FNab09001
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- TRK-fused gene
- Alternative Names
- FLJ36137 antibody, Protein TFG antibody, TF6 antibody, TFG antibody, TRK fused gene antibody, TRK fused gene protein antibody, TRKT3 antibody
- UniProt ID
- Q92734
- Observed MW
- 50-55 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:50-1:500
Validated Images
A549 cells were subjected to SDS PAGE followed by western blot with FNab09001(TFG antibody) at dilution of 1:400
Immunohistochemistry of paraffin-embedded human gliomas using FNab09001(TFG antibody) at dilution of 1:100
- Background
- Protein TFG(TRK-fused gene protein) plays a role in regulating phosphotyrosine-specific phosphatase-1 activity. Mutations in TFG may have important clinical relevance for current therapeutic strategies to treat metastatic melanoma. Defects in TFG are a cause of thyroid papillary carcinoma(TPC), a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Hereditary motor and sensory neuropathy with proximal dominant involvement(HMSN-P) is an autosomal-dominant neurodegenerative disorder characterized by widespread fasciculations, proximal-predominant muscle weakness, and atrophy followed by distal sensory involvement. Recent genetic investigation indicates that formation of TFG-containing cytoplasmic inclusions and concomitant mislocalization of TAR DNA-binding protein 43 kDa(TDP-43) underlie motor neuron degeneration in HMSN-P. Pathological overlap of proteinopathies involving TFG and TDP-43 highlights a new pathway leading to motor neuron degeneration.
