Products
TRIB3 antibody
- Product Name
- TRIB3 antibody
- Catalogue No.
- FNab08966
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- tribbles homolog 3(Drosophila)
- Alternative Names
- C20orf97 antibody, NIPK antibody, SINK antibody, SKIP3 antibody, TRB 3 antibody, TRB3 antibody, TRIB3 antibody, Tribbles homolog 3 antibody
- UniProt ID
- Q96RU7
- Observed MW
- 42 kDa
Application
- Tested Applications
- ELISA, WB, IP
- Recommended dilution
- WB: 1:500-1:5000; IP: 1:200-1:2000
Validated Images
mouse liver tissue were subjected to SDS PAGE followed by western blot with FNab08966(TRIB3 antibody) at dilution of 1:600
IP Result of anti-TRIB3 (IP:FNab08966, 4ug; Detection:FNab08966 1:500) with mouse liver tissue lysate 4000ug.
- Background
- Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA.
