Products
TCF7L2 antibody
- Product Name
- TCF7L2 antibody
- Catalogue No.
- FNab08556
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- transcription factor 7-like 2(T-cell specific, HMG-box)
- Alternative Names
- TCF4 antibody
- UniProt ID
- Q9NQB0
- Observed MW
- 68 kDa
Application
- Tested Applications
- ELISA, WB, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:2000
Validated Images
mouse liver tissue were subjected to SDS PAGE followed by western blot with FNab08556(TCF7L2 antibody) at dilution of 1:1000
IP Result of anti-TCF7L2 (IP:FNab08556, 4ug; Detection:FNab08556 1:1000) with mouse liver tissue lysate 4000ug.
- Background
- Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
