Apoptosised HeLa cells were subjected to SDS PAGE followed by western blot with FNab08391(SUMO2/3 antibody) at dilution of 1:100
Immunohistochemistry of paraffin-embedded human gliomas using FNab08391(SUMO2/3 antibody) at dilution of 1:50
Immunofluorescent analysis of HEK-293 cells using FNab08391 (SUMO2/3 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG(H+L)
Background
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.