MCF7 cells were subjected to SDS PAGE followed by western blot with FNab07771(SETDB1 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded rat brain using FNab07771(SETDB1 antibody) at dilution of 1:100
Background
This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.