Products
RUNX2 antibody
- Product Name
- RUNX2 antibody
- Catalogue No.
- FNab07536
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- runt-related transcription factor 2
- Alternative Names
- AML3 antibody, CBFA1 antibody, OSF2 antibody, PEBP2A antibody
- UniProt ID
- Q13950
- Observed MW
- 50-60 kDa
Application
- Tested Applications
- ELISA, WB
- Recommended dilution
- WB: 1:200-1:2000
Validated Images
MCF7 cell were subjected to SDS PAGE followed by western blot with FNab07536(RUNX2 Antibody) atdilution of 1:600
- Background
- Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element(OCFRE)(By similarity). Inhibits KAT6B-dependent transcriptional activation.
