Products
P53 antibody
- Product Name
- P53 antibody
- Catalogue No.
- FNab06083
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- tumor protein p53
- Alternative Names
- Antigen NY CO 13 antibody, Cellular tumor antigen p53 antibody, FLJ92943 antibody, LFS1 antibody, P53 antibody, Phosphoprotein p53 antibody, TP53 antibody, TRP53 antibody, tumor protein p53 antibody, Tumor suppressor p53 antibody
- UniProt ID
- P04637
- Observed MW
- 53 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF
- Recommended dilution
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:20 - 1:100
Validated Images
MCF7 cells were subjected to SDS PAGE followed by western blot with FNab06083(P53 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human endometrial cancer using FNab06083(P53 antibody) at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using FNab06083 (P53 Antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG (H+L)
- Background
- This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).
