Products
NDEL1 antibody
- Product Name
- NDEL1 antibody
- Catalogue No.
- FNab05601
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- nudE nuclear distribution gene E homolog(A. nidulans)-like 1
- Alternative Names
- EOPA antibody, MITAP1 antibody, NUDEL antibody
- UniProt ID
- Q9GZM8
- Observed MW
- 38-42kd
Application
- Tested Applications
- ELISA, WB, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:2000
Validated Images
human brain tissue were subjected to SDS PAGE followed by western blot with FNab05601(NDEL1 antibody) at dilution of 1:500
IP Result of anti-NDEL1 (IP:FNab05601, 4ug; Detection:FNab05601 1:300) with HepG2 cells lysate 2400ug.
- Background
- Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein-and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL.
