Products

NAT10 antibody

Synonyms:ALP antibody, KIAA1709 antibody
Catalogue No.:FNab05562Reativity:Human, Mouse, Rat
Host:RabbitTested Application:ELISA, WB, IF, IP
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
NAT10 antibody
Catalogue No.
FNab05562
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
N-acetyltransferase 10(GCN5-related)
Alternative Names
ALP antibody, KIAA1709 antibody
UniProt ID
Q9H0A0
Observed MW
116 kDa
Application
Tested Applications
ELISA, WB, IF, IP
Recommended dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IF: 1:20-1:200
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab05562( NAT10 Antibody) at dilution of 1:3000
IP Result of anti-NAT10 (IP:FNab05562, 2ug; Detection:FNab05562 1:500) with mouse testis tissue lysate 4000ug.
Background
RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs(PubMed:25653167). Catalyzes the formation of N(4)-acetylcytidine(ac4C) at positions 1337 and 1842 in 18S rRNA(By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis(PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs(By similarity). Requires the tRNA-binding adapter protein THUMBD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation(PubMed:25653167). Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division(PubMed:14592445, PubMed:17631499, PubMed:18082603, PubMed:19303003).