Products
IL1R2 antibody
- Product Name
- IL1R2 antibody
- Catalogue No.
- FNab04243
- Size
- 100μg
- Form
- liquid
- Purification
- Protein A+G purification
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- monoclonal
- Isotype
- IgG1
- Clone ID
- 7G9
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- interleukin 1 receptor, type II
- Alternative Names
- CD121b antibody, CDw121b antibody, IL 1R 2 antibody, IL 1R beta antibody, IL 1RT 2 antibody, IL 1RT2 antibody, IL1 Receptor 2 antibody, IL-1 Receptor 2 antibody, IL1 Receptor II antibody, IL-1 Receptor II antibody, IL1R2 antibody, IL1RB antibody, IL-1RII antibody, Interleukin 1 receptor beta antibody, Interleukin 1 receptor type 2 antibody, Interleukin 1 receptor type II antibody
- UniProt ID
- P27930
- Observed MW
- 45 kDa
Application
- Tested Applications
- ELISA, WB, IF
- Recommended dilution
- WB: 1:500-1:2000; IF: 1:20-1:200
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab04243(IL1R2 antibody) at dilution of 1:1000
- Background
- Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2(membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
