Products
HTRA1 antibody
- Product Name
- HTRA1 antibody
- Catalogue No.
- FNab04069
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- HtrA serine peptidase 1
- Alternative Names
- HTRA antibody, PRSS11 antibody
- UniProt ID
- Q92743
- Observed MW
- 35 kDa, 50 kD, 42 kDa
Application
- Tested Applications
- ELISA, WB, IF, IP, IHC
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200
Validated Images
L02 cells were subjected to SDS PAGE followed by western blot with FNab04069(HTRA1 antibody) at dilution of 1:600
IP Result of anti-HTRA1 (IP:FNab04069, 4ug; Detection:FNab04069 1:500) with L02 cells lysate 1400ug.
Immunohistochemistry of paraffin-embedded human placenta tissue slide using FNab04069(HTRA1 Antibody) at dilution of 1:200
- Background
- Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors(IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.
