mouse liver tissue were subjected to SDS PAGE followed by western blot with FNab03928(HMGCL antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human kidney using FNab03928(HMGCL antibody) at dilution of 1:100
Background
The protein encoded by this gene belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.