Products
FAM20C antibody
- Product Name
- FAM20C antibody
- Catalogue No.
- FNab02979
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- family with sequence similarity 20, member C
- Alternative Names
- Dentin matrix protein 4 antibody, DMP 4 antibody, DMP4 antibody, FAM20C antibody, Protein FAM20C antibody, RNS antibody
- UniProt ID
- Q8IXL6
- Observed MW
- 50 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:20-1:200
Validated Images
various lysates were subjected to SDS PAGE followed by western blot with FNab02979(FAM20C Antibody) at dilution of 1:600
Immunohistochemistry of paraffin-embedded human kidney tissue slide using FNab02979(FAM20C Antibody) at dilution of 1:50
- Background
- Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth(PubMed:22582013, PubMed:23754375, PubMed:25789606). Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome(PubMed:26091039). Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity(PubMed:26091039). Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1(PubMed:22582013, PubMed:25789606). In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion(PubMed:26091039).
