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CYLD antibody
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Research Area:
- SPECIFICATIONS
- Product Name
- CYLD antibody
- Catalogue No.
- FNab02142
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- cylindromatosis(turban tumor syndrome)
- Alternative Names
- CYLD1 antibody, KIAA0849 antibody
- UniProt ID
- Q9NQC7
- Observed MW
- 110 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IP
- Recommended dilution
- WB: 1:500-1:1000; IP: 1:200-1:1000; IHC: 1:50-1:500
Validated Images
A431 cells were subjected to SDS PAGE followed by western blot with FNab02142(CYLD antibody) at dilution of 1:500
IP Result of anti-CYLD (IP: FNab02142, 4ug; Detection: FNab02142 1:300) with mouse brain tissue lysate 4000ug.
Immunohistochemistry of paraffin-embedded human colon cancer using FNab02142(CYLD antibody) at dilution of 1:50
- Background
- Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation(PubMed:12917689, PubMed:12917691). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation(PubMed:12917690). Negative regulator of Wnt signaling(PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules(PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis(PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis(PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation(PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis(By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation(By similarity).