Products
CHI3L1 antibody
- Product Name
- CHI3L1 antibody
- Catalogue No.
- FNab01649
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- chitinase 3-like 1(cartilage glycoprotein-39)
- Alternative Names
- 39 kDa synovial protein antibody, ASRT7 antibody, Cartilage glycoprotein 39 antibody, CGP 39 antibody, CHI3L1 antibody, Chitinase 3 like protein 1 antibody, GP 39 antibody, GP39 antibody, HC gp39 antibody, hCGP 39 antibody, HCGP 3P antibody, YKL 40 antibody, YKL40 antibody, YYL 40 antibody
- UniProt ID
- P36222
- Observed MW
- 43 kDa
Application
- Tested Applications
- ELISA, IHC
- Recommended dilution
- IHC: 1:50 - 1:200
Validated Images
Immunohistochemistry of paraffin-embedded human liver tissue using FNab01649(CHI3L1 antibody) at dilution of 1:100
- Background
- Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2(Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.
