Products

Autotaxin antibody

Synonyms:ATX antibody, ATX X antibody, Autotaxin antibody, E NPP 2 antibody, ENPP2 antibody, FLJ26803 antibody, LysoPLD antibody, PD IALPHA antibody, PDNP2 antibody
Catalogue No.:FNab00749Reativity:Human, Mouse, Rat
Host:RabbitTested Application:ELISA, WB, IHC, IP
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
Autotaxin antibody
Catalogue No.
FNab00749
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
ectonucleotide pyrophosphatase/phosphodiesterase 2
Alternative Names
ATX antibody, ATX X antibody, Autotaxin antibody, E NPP 2 antibody, ENPP2 antibody, FLJ26803 antibody, LysoPLD antibody, PD IALPHA antibody, PDNP2 antibody
UniProt ID
Q13822
Observed MW
100kd
Application
Tested Applications
ELISA, WB, IHC, IP
Recommended dilution
WB: 1:500-1:1000; IP: 1:500-1:1000; IHC: 1:20-1:200
Validated Images
mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab00749(ENPP2 antibody) at dilution of 1:500
IP Result of anti-Autotaxin (IP:FNab00749, 5ug; Detection:FNab00749 1:500) with mouse brain tissue lysate 4000ug.
Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using FNab00749(ENPP2 Antibody) at dilution of 1:50
Background
Hydrolyzes lysophospholipids to produce lysophosphatidic acid(LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.