Products
APP antibody
- Product Name
- APP antibody
- Catalogue No.
- FNab00513
- Size
- 100μg
- Form
- liquid
- Purification
- Protein A+G purification
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- monoclonal
- Isotype
- IgG2a
- Clone ID
- 8B9
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- amyloid beta A4 precursor protein
- Alternative Names
- A4 antibody, ABPP antibody, Alzheimer disease amyloid protein antibody, Cerebral vascular amyloid peptide antibody, Beta-amyloid precursor protein antibody, CVAP antibody, PreA4 antibody
- UniProt ID
- P05067
- Observed MW
- 100 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:50-1:500
Validated Images
HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab00513(APP Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human gliomas tissue slide using FNab00513(APP Antibody) at dilution of 1:200
- Background
- Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Beta-amyloid 42 is a more effective reductant than beta-amyloid 40. Beta-amyloid peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Also binds GPC1 in lipid rafts.The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.
