Products
ADAR1 antibody
- Product Name
- ADAR1 antibody
- Catalogue No.
- FNab00150
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- adenosine deaminase, RNA-specific
- Alternative Names
- ADAR antibody, ADAR1 antibody, adenosine deaminase antibody, RNA antibody, DRADA antibody, DSH antibody, DSRAD antibody, G1P1 antibody, IFI 4 antibody, IFI4 antibody, Interferon inducible protein 4 antibody, K88dsRBP antibody, p136 antibody
- UniProt ID
- P55265
- Observed MW
- 110 kDa
Application
- Tested Applications
- ELISA, IHC, IF, WB, IP
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:50-1:200; IP: 1:200-1:1000; IF: 1:20-1:200
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab00150(ADAR1 Antibody) at dilution of 1:1000
IP Result of anti-ADAR1 (IP:FNab00150, 4ug; Detection:FNab00150 1:500) with Y79 cells lysate 3000ug.
Immunohistochemistry of paraffin-embedded human gliomas using FNab00150(ADAR1 antibody) at dilution of 1:50
- Background
- ADAR1 is also named as ADAR1, DSRAD, G1P1, IFI4. It convert selected adenosine residues into inosine in substrate RNAs containing a relatively short dsRNA region(PMID:15556947). The human ADAR1 gene specifies two size forms of RNA-specific adenosine deaminase, an interferon(IFN) inducible ?150 kDa protein and a constitutively expressed N-terminally truncated ?110 kDa protein, encoded by transcripts with alternative exon 1 structures that initiate from different promoters(PMID:11111054). It has 5 isoforms produced by alternative promoter usage and alternative splicing. Defects in ADAR are a cause of dyschromatosis symmetrical hereditaria(DSH).ADAR1 can form respective homodimers, and this association is essential for its enzymatic activities(PMID:17428802).
