Products
ACD antibody
- Product Name
- ACD antibody
- Catalogue No.
- FNab00078
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- adrenocortical dysplasia homolog(Mouse)
- Alternative Names
- ACD antibody, PIP1 antibody, PTOP antibody, TINT1 antibody, TPP1 antibody
- UniProt ID
- Q96AP0
- Observed MW
- 58 kDa
Application
- Tested Applications
- ELISA, WB
- Recommended dilution
- WB: 1:500-1:5000
Validated Images
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab00078(ACD Antibody) at dilution of 1:1500
- Background
- Component of the shelterin complex(telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.
