Products
ABAT antibody
- Product Name
- ABAT antibody
- Catalogue No.
- FNab00026
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- 4-aminobutyrate aminotransferase
- Alternative Names
- ABAT antibody, FLJ17813 antibody, GABA aminotransferase antibody, GABA AT antibody, GABA T antibody, GABA transaminase antibody, GABAT antibody, L AIBAT antibody
- UniProt ID
- P80404
- Observed MW
- 49 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF
- Recommended dilution
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
Validated Images
human liver tissue were subjected to SDS PAGE followed by western blot with FNab00026(ABAT antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human pancreas cancer using FNab00026(ABAT antibody) at dilution of 1:100
Immunofluorescence analysis of A549 cells using FNab00026(ABAT antibody). Blue: DAPI for nuclear staining.
- Background
- 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
