Autoimmune Disease (AID) is a kind of diseases in which the body’s immune system mistakenly attacks its own normal cells or tissues, resulting in inflammation and damage. More than 100 types of AID have been identified with a prevalence rate of up to 15%. The presence of one or more autoantibodies (AAb) in the serum is an important marker of AID. Detecting AAb during a physical examination can help diagnose AID, monitor the activity of AID and the effectiveness of treatment, and prevent the occurrence and development of AID.