| Synonyms: | ARVC10, ARVD10, Cadherin family member 5, CDHF5, desmoglein 2, DSG2, HDGC |
| Catalogue No.: | FNab10768 |
| Host: | Rabbit |
| Reactivity: | Human, Mouse, Rat |
| Test Application: | ELISA, WB, IHC, IF |
| Size: | 100µg |
| Form: | liquid |
| Purification: | Immunogen affinity purified |
| Purity: | ≥95% as determined by SDS-PAGE |
| Clonality: | polyclonal |
| Isotype: | IgG |
| UniProt ID: | Q14126 |
| Storage: | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| Image: | 
Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using FNab10768(DSG2 antibody) at dilution of 1:100.
Immunofluorescent analysis of A431 cells using FNab10768(DSG2 antibody) at dilution of 1:100.
Various lysates were subjected to SDS PAGE followed by western blot with FNab10768(DSG2 antibody) at dilution of 1:1000. |
- Antigen affinity purification, high purity;
- Applied in various species and validations: e.g. ELISA, WB, IHC, IF;
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REFERENCES
[1] Extracellular vesicles from immortalized cardiosphere-derived cells attenuate arrhythmogenic cardiomyopathy in desmoglein-2 mutant mice, PMID: 34345905.
[2] Desmoglein-2 as a prognostic and biomarker in ovarian cancer, PMID: 33218274.
[3] Desmoglein 2 regulates cardiogenesis by restricting hematopoiesis in the developing murine heart, PMID: 34737300.
[4] Desmoglein-2 harnesses a PDZ-GEF2/Rap1 signaling axis to control cell spreading and focal adhesions independent of cell-cell adhesion, PMID: 34168237.
[5] Desmoglein-2 modulates tumor progression and osimertinib drug resistance through the EGFR/Src/PAK1 pathway in lung adenocarcinoma, PMID: 32272148.