|Synonyms:||ARVC10, ARVD10, Cadherin family member 5,
CDHF5, desmoglein 2, DSG2, HDGC
|Reactivity:||Human, Mouse, Rat|
|Test Application:||ELISA, WB, IHC, IF|
|Purification:||Immunogen affinity purified|
|Purity:||≥95% as determined by SDS-PAGE|
|Storage:||PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)|
Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using FNab10768(DSG2 antibody) at dilution of 1:100.
Immunofluorescent analysis of A431 cells using FNab10768(DSG2 antibody) at dilution of 1:100.
Various lysates were subjected to SDS PAGE followed by western blot with FNab10768(DSG2 antibody) at dilution of 1:1000.
- Antigen affinity purification, high purity;
- Applied in various species and validations: e.g. ELISA, WB, IHC, IF;
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 Extracellular vesicles from immortalized cardiosphere-derived cells attenuate arrhythmogenic cardiomyopathy in desmoglein-2 mutant mice, PMID: 34345905.
 Desmoglein-2 as a prognostic and biomarker in ovarian cancer, PMID: 33218274.
 Desmoglein 2 regulates cardiogenesis by restricting hematopoiesis in the developing murine heart, PMID: 34737300.
 Desmoglein-2 harnesses a PDZ-GEF2/Rap1 signaling axis to control cell spreading and focal adhesions independent of cell-cell adhesion, PMID: 34168237.
 Desmoglein-2 modulates tumor progression and osimertinib drug resistance through the EGFR/Src/PAK1 pathway in lung adenocarcinoma, PMID: 32272148.