Desmoglein-2 (DSG2) Antibody with High Purity

Cell desmosome is a multiprotein complex and functions as the intercellular anchoring junction in the tissue. Palmitoylation on Desmoglein-2(Dsg2) plays an important role in the assembly of desmosome. The down-regulated expression of Dsg2 is usually found in gastric cancer, prostate cancer, melanoma, pancreatic cancer and colon cancer. Overexpression of Dsg2 appears in cutaneous squamous cell carcinoma, basal cell carcinoma, non small cell lung cancer.
Synonyms: ARVC10, ARVD10, Cadherin family member 5,
CDHF5, desmoglein 2, DSG2, HDGC
Catalogue No.: FNab10768
Host: Rabbit
Reactivity: Human, Mouse, Rat
Test Application: ELISA, WB, IHC, IF
Size: 100µg
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Clonality: polyclonal
Isotype: IgG
UniProt ID: Q14126
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Image: desmoglein-2-ihc

Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using FNab10768(DSG2 antibody) at dilution of 1:100.



Immunofluorescent analysis of A431 cells using FNab10768(DSG2 antibody) at dilution of 1:100.



Various lysates were subjected to SDS PAGE followed by western blot with FNab10768(DSG2 antibody) at dilution of 1:1000.

  • Antigen affinity purification, high purity;
  • Applied in various species and validations: e.g. ELISA, WB, IHC, IF;
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[1] Extracellular vesicles from immortalized cardiosphere-derived cells attenuate arrhythmogenic cardiomyopathy in desmoglein-2 mutant mice, PMID: 34345905.
[2] Desmoglein-2 as a prognostic and biomarker in ovarian cancer, PMID: 33218274.
[3] Desmoglein 2 regulates cardiogenesis by restricting hematopoiesis in the developing murine heart, PMID: 34737300.
[4] Desmoglein-2 harnesses a PDZ-GEF2/Rap1 signaling axis to control cell spreading and focal adhesions independent of cell-cell adhesion, PMID: 34168237.
[5] Desmoglein-2 modulates tumor progression and osimertinib drug resistance through the EGFR/Src/PAK1 pathway in lung adenocarcinoma, PMID: 32272148.