FineTest ELISA kit contributes to the research on neuropathic pain treatment. The immunoassay is designed to measure Norepinephrine (NE), epinephrine (E), and dopamine (DA) level in serum.
Article Title: Auricular vagus nerve stimulation drives analgesia via an auricle–brain axis in a mouse model of neuropathic pain
Journal Title: Nature Communications
DOI: 10.1038/s41467-026-72214-0
IF: 18.1
PMID: 42014724
Abstract: Despite its long-recognized effects in relieving pain, the neural substrates of auricular stimulation remain elusive. Here, we show that trans-auricular vagus nerve stimulation (taVNS), i.e., electrical stimulation of the auricular concha, effectively induces analgesia in a mouse model of neuropathic pain. Viral tracing, microendoscopic calcium imaging, and multi-electrode recordings reveal that auricular vagal signals travel to the jugular-nodose ganglia (JNG), which in turn connect to pro-opiomelanocortinergic neurons in nucleus tractus solitarius (NTS), subsequently activating glutamatergic neurons in ventrolateral periaqueductal gray (vlPAG). Optogenetic stimulation of central vagus terminals, JNG-derived auricular peripheral fibers, or vlPAG-projecting NTS neurons mimics taVNS-induced analgesia, whereas chemogenetic silencing of central vagus terminals or NTS neurons abolishes this effect. This study identifies an auricle-to-brain circuit underlying taVNS-driven analgesia in mice, with potential for facilitating taVNS optimization for pain management and other neurological conditions.
Keywords: Neural circuits, Sensory processing, Neuropathic pain, Neuralgia
Immunoassay
| FineTest Product | Sample | Species | Detection Target |
| NA/NE(Noradrenaline/Norepinephrine) ELISA Kit(EU2565) | serum | mouse | NE |
| EPI(Epinephrine/Adrenaline) ELISA Kit(EU2563) | EPI | ||
| DA(Dopamine) ELISA Kit(EU0392) | DA |
Validated Image
Figure Source: Nat Commun. 2026 Apr 21;17(1):5481. doi: 10.1038/s41467-026-72214-0.