[Cited FineTest ELISA Kit] Current Research on Epithelial Cancer Treatment

FineTest ELISA kit contributes to the research on epithelial cancer treatment. The immunoassay is designed to measure TNF-α level in supernatants.

Article Title: The CXCL10-CXCR3 Axis Induces Tumor-Associated Neutrophils to Interfere with CTLs-Mediated Antitumor Activity in EBV-Associated Epithelial Cancers
Journal Title: Advanced Science
DOI: 10.1002/advs.202500950
IF: 14.1
PMID: 40686457

Abstract: Although Epstein-Barr virus (EBV)-associated epithelial cancers are categorized as immunologically "hot" tumors, they have unsatisfactory responses to immunotherapy. Increasing evidence has shown that therapeutic failure is due to an immunosuppressive tumor microenvironment established by EBV. In this study, a negative correlation is found between the infiltration of neutrophils and that of cytotoxic T lymphocytes (CTLs) containing granzyme B in EBV-associated epithelial cancers. The CXCL10-CXCR3 axis in EBV-associated epithelial cancer cells controls the extrusion of neutrophil extracellular traps (NETs), which interferes with the antitumor activity of EBV antigen-specific T cells in vitro and in vivo. NETs are positively correlated with the number of dysfunctional CTLs in EBV-associated epithelial cancers, and are confirmed to be an independent prognostic factor for patients with EBV-associated epithelial cancers. In conclusion, these findings reveal a novel mechanism of immunosuppression of tumor-associated neutrophils (TANs) in EBV-associated epithelial cancers. Targeting NETs formation in TANs may be a potential strategy for improving the efficacy of immunotherapy against EBV-associated epithelial cancers.

Keywords: EBV, EBVaGC, NPC, neutrophil extracellular traps, tumor‐associated neutrophils, epithelial cancer

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Figure Source: Adv Sci (Weinh). 2025 Jul 21:e00950. doi: 10.1002/advs.202500950.