FineTest ELISA kit contributes to the research on allergic asthma treatment. The immunoassay is designed to measure Testosterone/Estradiol/IL-4/IL-5/IL-13 level in supernatant and serum.
Article Title: Androgen signaling via sympathetic neurons regulates allergic pulmonary inflammation
Journal Title: Science Immunology
DOI: 10.1126/sciimmunol.aed0186
IF: 16.4
PMID: 42627933
Abstract: Sex differences in the rates of asthma onset and remission suggest that sex hormones may play an important role in the pathogenic mechanism underlying certain forms of asthma. Here, we demonstrate that increased endogenous androgen production in male mice can mitigate pulmonary type 2 inflammation after repeated allergen exposures during early life. Building on previous work showing that immune cells can respond to androgen signaling, we report that androgens also promote pulmonary sympathetic innervations, which can dampen type 2 inflammation via the neurotransmitter norepinephrine. Ablation of the androgen signal in sympathetic neurons is sufficient to disturb the establishment of sympathetic structures in the lungs of male mice, thereby amplifying type 2 inflammatory responses to allergens. Thus, an endocrine-neuroimmune axis contributes to the sexual dimorphism of allergic asthma during development.
Keywords: Allergic asthma treatment, Androgens, Pneumonia, Pulmonary inflammation
Immunoassay
| FineTest Product | Sample | Species | Detection Target |
| Mouse T(Testosterone) ELISA Kit(EM1850-HS) | supernatant/serum | mouse | Testosterone |
| E2(Estradiol) ELISA Kit(EU0390) | Estradiol | ||
| Mouse IL-4(Interleukin 4) ELISA Kit(EM0119) | IL-4 | ||
| Mouse IL-5(Interleukin 5) ELISA Kit(EM0120) | IL-5
|
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| Mouse IL-13(Interleukin 13) ELISA Kit(EM0103) | IL-13 |
Validated Image
Figure Source: Sci Immunol. 2026 Aug 21;11(122):eaed0186. doi: 10.1126/sciimmunol.aed0186.