[Cited FineTest Antibody] Current Research on Gastric Tumor

FineTest Antibody contributes to the research on gastric tumor. The western blot is designed to measure DHRS3 in HGC-27 cells.

Publication Details
Article Title:      Anti-tumor activity of all-trans retinoic acid in gastric-cancer: gene-networks and molecular mechanisms
Journal Title:   Journal of Experimental & Clinical Cancer Research
DOI: 10.1186/s13046-023-02869-w
IF: 11.3
PMID: 37951921

Abstract:    Gastric cancer is a heterogeneous type of neoplastic disease and it lacks appropriate therapeutic options. There is an urgent need for the development of innovative pharmacological strategies, particularly in consideration of the potential stratified/personalized treatment of this tumor. We evaluated the anti-proliferative action of ATRA in HGC-27 cells and tissue-slice cultures from 13 patients. Profiling of our large panel of gastric-cancer cell-lines for their quantitative response to the anti-proliferative effects of ATRA indicate that approximately half of the cell-lines are characterized by sensitivity to the retinoid. Our data represent the fundaments for the design of clinical trials focusing on the use of ATRA in the personalized treatment of this heterogeneous tumor. The immune-regulatory responses activated by ATRA suggest that the retinoid and immune-checkpoint inhibitors constitute rational combinations for the management of gastric cancer.

Keywords:  Gastric cancer, All-trans-retinoic-acid, IRF1, Immune-responses, RNA-sequencing

Western Blot

Validated Image

Figure Source: J Exp Clin Cancer Res. 2023 Nov 11;42(1):298. doi: 10.1186/s13046-023-02869-w.