【Cited FineTest Elisa Kit】 Current Research on Precision Medicine and Nanotechnology

FineTest Elisa kit contributes to the research on precision medicine and nanotechnology. The immunoassay is designed to measure PDGF-BB concentration in DNA samples.

Publication Details
Article Title:    Engineering a Second-Order DNA Logic-Gated Nanorobot to Sense and Release on Live Cell Membranes for Multiplexed Diagnosis and Synergistic Therapy
Journal Title:  Angewandte Chemie
DOI: 10.1002/anie.202103993
IF: 15.336
PMID: 33908144

Abstract:     Tumor biomarker-based theranostics have achieved broad interest and success in recent years. However, single biomarker-based recognition can cause false-positive feedback, including the on-target off-tumor phenomenon, in the absence of tumor-specific antigen. Multibiomarker-based recognition molecules often elicit nonspecific and undesired internalization when they bind to "bystander" cells. We report a universal DNA tetrahedral scaffold (DTS) that anchors on the cell membrane to load multiple aptamers and therapeutics for precise and effective theranostics. This DNA logic-gated nanorobot (DLGN) not only facilitates precise discrimination among five cell lines, but also triggers synergistic killing of effector aptamer-tethered synergistic drugs (EASDs) to target cancer cells. Logic-gated recognition integrated into aptamer-functionalized molecular machines will prompt fast tumor profiling, in situ capture and isolation, and safe delivery of precise medicine.
Keywords:  DNA Nanorobots, Logic Gates, Synergistic Therapy, Theranostics, Tumor Classification, Precision Medicine

Immunoassay