High IF Citations

【Cited FineTest Elisa Kit】 Current Research on Neurotrauma

FineTest Elisa kit contributes to the research on neurotrauma. The immunoassay is designed to measure S100B concentration in patients' blood.

Publication Details
Article Title: Prior nasal delivery of antagomiR-122 prevents radiation-induced brain injury
Journal Title: Molecular Therapy
DOI: 10.1016/j.ymthe.2021.06.019
IF: 11.454
PMID: 34174438

Abstract:       Radiation-induced brain injury is a major adverse event in head and neck tumor treatment, influencing the quality of life for the more than 50% of patients who undergo radiation therapy and experience long-term survival. However, no effective treatments are available for these patients, and preventative drugs and effective drug-delivery methods must be developed. Based on our results, miR-122-5p was upregulated in the mouse radiation-induced brain injury (RBI) model and patients with nasopharyngeal carcinoma (NPC) who received radiation therapy. Intranasal administration of a single antagomiR-122-5p dose before irradiation effectively alleviated radiation-induced cognitive impairment, neuronal injury, and neuroinflammation in the mouse RBI model. Results further indicated that miR-122-5p inhibition in microglia reduced the levels of proinflammatory cytokines and enhanced the phagocytic function to protect against radiation-induced neuronal injury in cell models. Further, we profiled transcriptome data and verified that Tensin 1 (TNS1) may be the target of miR-122-5p in RBI. In summary, our results reveal a distinct role for miR-122-5p in regulating neuroinflammation in RBI, indicating that a non-invasive strategy for intranasal miR-122-5p administration may be an attractive therapeutic target in RBI, providing new insights for clinical trials. Further systematic safety assessment, optimization of drug administration, and clarity of mechanism will accelerate the process into clinical practice.
Keywords:    miR-122-5p, Microglia, Nasal Delivery, Radiation-induced Brain Injury, Neurotrauma

Immunoassay

FineTest Product Sample Detection Target Species
Human S100B(Protein S100-B) ELISA Kit (EH0543) blood S100B Human