Monkeypox Overview Monkeypox virus is a self-limiting zoonotic disease caused by DNA virus. It has the typical form of orthopoxvirus, with rounded brick or oval shape and size of 200-400m. Components: brick-shaped or oval-shaped, covered by a protein membrane or envelope, with two protein-containing side bodies in the middle, and a thick membrane core. The …
Background Cell desmosome is a multiprotein complex and functions as the intercellular anchoring junction in the tissue. Palmitoylation on Desmoglein-2(Dsg2) plays an important role in the assembly of desmosome. The down-regulated expression of Dsg2 is usually found in gastric cancer, prostate cancer, melanoma, pancreatic cancer and colon cancer. Overexpression of Dsg2 appears in cutaneous squamous …
Background ACE (peptidyl-dipeptidase A) is a kind of zinc metallopeptidase, which plays an important role in blood-pressure control and water-salt metabolism. The widely expressed ACE shows the highest content in lung, kidney, heart, gastrointestinal system and prostate. ACE has two main functions: 1. catalyze and convert angiotensin I into angiotensin II; 2. inactivate bradykinin. Thus, …
Abstract: The PI3K/AKT/mTOR signaling pathway plays a key role in regulating growth and metabolism. The metabolism of energy is usually accompanied by the metabolism of substances, and the cycle of substances is also accompanied by the generation and utilization of energy. Such a process should be well adjusted to maintain the stability of …
Abstract: Poly(ADP-ribose) polymerase (PARP) is located in the nucleus and belongs to the DNA-repairing enzyme under stress condition. PARP1 plays an important role in DNA damage repair by labelling DNA damage sites and recruiting relevant DNA repair proteins. Keywords: DNA Damage Repair, DNA-repairing Enzyme, PARP1 Protein 1. DNA Damage Repair Pathways Prof. …
Abstract: Rapid antigen antibody test plays an important role in screening SARS-CoV-2 and also coordinates with nucleic acid testing in early testing for suspected patients suffering from COVID-19. Thus, infection sources can be controlled by the subsequent large-scale screening in the shortest time. Keywords: Rapid Antigen Antibody Test, SARS-CoV-2, Colloidal Gold Antigen Test, …
Abstract: Based on customers’ real requirements, FineTest ELISA researchers develop and optimize product performance. For many years’ experience, the amount of ELISA kits is increasing and the performance is improved. The product quality is widely trusted by customers. Since our R & D team resolves the core technology, the new released accquant series …
Abstract: Currently, the general epidemic situation in China is steady. However, it’s reported that sporadic cases appear in many places. With the decrease of the temperature, the virus activity increases. The work for preventing rebound of the epidemic is heavier. Hence, the research of COVID-19 products still has great value. The competition is intense. …
Structure of 2019-nCoV 2019 novel coronavirus is also called 2019-nCoV, SARS-CoV-2, SARS-CoV2. Novel coronavirus and SARS coronavirus (SARS-CoV) are of the same class, but not the same species, with single-stranded RNA genes. 4 types of main Structure protein: Spike Surface Glycoprotein (S) Envelope Protein (E) Matrix Protein (M) Nucleocapsid Protein (N) 2019-nCoV related protein S …
What is S protein, why is it so important? S protein is currently considered to be one of the most promising targets for the development of coronavirus vaccines and is being used in the development of vaccines against human coronavirus. We could see from above diagram, the main structural proteins of 2019-nCoV are as follows:spike …
